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Can we take the STING out of bone loss? Pathway presents potential treatment target for skeletal aging
As we age, our bones become weak and brittle, a process called osteoporosis. This bone loss is caused by changes in the cells within the bone marrow microenvironment, such as elevated fat and inflammation-promoting immune cells.
AI Summary
Researchers found that the STING signaling pathway becomes activated in bone marrow macrophages as people age. The activation occurs alongside increased fat and inflammation‑promoting immune cells in the bone marrow microenvironment, which contribute to osteoporosis. The study, published in Advanced Science, shows that targeting the STING pathway could help prevent age‑related bone loss.
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