AI Summary

Scientists from the Broad Institute, Harvard Medical School, and McLean Hospital showed that the DNA repeat expansion that drives Huntington’s disease also expands in the neocortex, not just the striatum. The repeat grows slowly over a person’s life and becomes toxic once it enlarges severalfold. The study, published in Cell, demonstrates that this toxic expansion occurs in another brain region damaged by the disease. The findings support ongoing drug development aimed at targeting the repeat‑expansion mechanism to protect multiple brain areas.

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