Bad neighbors: How immune cells help cancer cells get ready to spread | HappeningNow.news

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Bad neighbors: How immune cells help cancer cells get ready to spread

Most cancer deaths are not caused by the original tumor, but by metastases, which form when cancer cells leave the original tumor and spread to other organs.

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Researchers at the Université libre de Bruxelles identified that immune cells form distinct “neighborhoods” around cancer cells, with one specific neighborhood facilitating cancer spread. In this zone, immune cells communicate with tumor cells, enhancing their ability to detach, become mobile, and undergo the epithelial‑to‑mesenchymal transition that drives metastasis. The study highlights that cancer cells in an intermediate “hybrid” stage are especially adept at forming metastases, and that immune‑cell interactions can promote this transition, directly contributing to the formation of distant secondary tumors.

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