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Autoimmune disease linked to poor outcomes with myelodysplastic syndrome

Having a preexisting autoimmune disease is an independent risk factor for poor outcomes with myelodysplastic syndrome (MDS), according to a study published in the June issue of Clinical Immunology .

Source AI Summary Published May 30, 2026 Brief Under 1 min brief
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A retrospective study of 161 myelodysplastic syndrome patients who received allogeneic hematopoietic stem cell transplants between 2013 and 2024 found that those with preexisting autoimmune disease (39 patients) experienced poorer transplant outcomes than matched controls. Specifically, the autoimmune group had lower platelet engraftment, higher relapse rates, and reduced leukemia‑free survival and graft‑versus‑host disease‑free, relapse‑free survival, while overall survival and rates of acute or chronic GVHD did not differ.

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